Recent Advances and Contradictions in the Study of the Individual Roles of Ubiquitin Ligases That Regulate RIG-I-Like Receptor-Mediated Antiviral Innate Immune Responses

RIG-I and MDA5 are cytoplasmic viral RNA sensors and are essential for antiviral innate immune responses, such as type I interferon production.Post-translational modification is critical for the activation and inactivation of RIG-I catherine lansfield ombre rainbow clouds eyelet curtains and MDA5.At least seven ubiquitin ligases have been reported

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Results from the CLUES study: a cluster randomized trial for the evaluation of cardiovascular guideline implementation in primary care in Spain

Abstract Background The implementation of evidence-based clinical practice guidelines (CPG) can improve patients care.To date, the impact of implementation strategies has not been evaluated in our context.This study is aimed to evaluate the effectiveness of a multifaceted tailored intervention targeting clinician education for the implementation uc

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